"Stay in your lane, Bro." - AT&T First Tattoo. Punctuated by the expression on the tattooee's face at the end, slightly out of focus in the background.
"Don't smell like Walter!" - Aspercreme. Again, the look on the young gal's face.
"The primary purpose of a liberal education is to make one's mind a pleasant place in which to spend one's leisure."
- Sydney J. Harris
That's not a one-liner, but I like that one as well. Not only is the kid cute, but so is Amy Poehler!
Another one I always get a kick out of is the stodgy librarian yelling, “HOLY MOLY, THAT'S A LOT OF MILES!” -- Capital One Venture Card library spot. The lovely Jennifer Garner coyly and politely shushes her.
"The primary purpose of a liberal education is to make one's mind a pleasant place in which to spend one's leisure."
- Sydney J. Harris
The series of TV ads for Intuit QuickBooks featuring Danny DeVito has some memorable one-liners, such as: "Where's YOUR belly rubs?"
"You may do corgis, but you don't have to work like a dog."
"Your job isn't doing hard work, it's making HER do hard work...and getting paid for it!"
"Without you we wouldn't have electricity; our hobby would be going to bed early."
"The primary purpose of a liberal education is to make one's mind a pleasant place in which to spend one's leisure."
- Sydney J. Harris